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Regulators Discover a Hidden Viral Gene in Commercial GMO Crops
Posted By admin On January 21, 2013 @ 11:28 am In Sci Tech | Comments Disabled
Jonathan Latham and Allison Wilson
Independent Science News 
Jan 21, 2013
How should a regulatory agency announce they have discovered something potentially very important about the safety of products they have been approving for over twenty years?
In the course of analysis to identify potential allergens in GMO crops, the European Food Safety Authority (EFSA) has belatedly discovered that the most common genetic regulatory sequence in commercial GMOs also encodes a significant fragment of a viral gene (Podevin and du Jardin 2012) . This finding has serious ramifications for crop biotechnology and its regulation, but possibly even greater ones for consumers and farmers. This is because there are clear indications that this viral gene (called Gene VI) might not be safe for human consumption. It also may disturb the normal functioning of crops, including their natural pest resistance.
What Podevin and du Jardin discovered is that of the 86 different transgenic events (unique insertions of foreign DNA) commercialized to-date in the United States 54 contain portions of Gene VI within them. They include any with a widely used gene regulatory sequence called the CaMV 35S promoter (from the cauliflower mosaic virus; CaMV). Among the affected transgenic events are some of the most widely grown GMOs, including Roundup Ready soybeans (40-3-2) and MON810 maize. They include the controversial NK603 maize recently reported as causing tumors in rats (Seralini et al. 2012 ).
The researchers themselves concluded that the presence of segments of Gene VI “might result in unintended phenotypic changes”. They reached this conclusion because similar fragments of Gene VI have already been shown to be active on their own (e.g. De Tapia et al. 1993). In other words, the EFSA researchers were unable to rule out a hazard to public health or the environment.
In general, viral genes expressed in plants raise both agronomic and human health concerns (reviewed in Latham and Wilson 2008 ). This is because many viral genes function to disable their host in order to facilitate pathogen invasion. Often, this is achieved by incapacitating specific anti-pathogen defenses. Incorporating such genes could clearly lead to undesirable and unexpected outcomes in agriculture. Furthermore, viruses that infect plants are often not that different from viruses that infect humans. For example, sometimes the genes of human and plant viruses are interchangeable, while on other occasions inserting plant viral fragments as transgenes has caused the genetically altered plant to become susceptible to an animal virus (Dasgupta et al. 2001). Thus, in various ways, inserting viral genes accidentally into crop plants and the food supply confers a significant potential for harm.
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URLs in this post:
 Independent Science News: http://independentsciencenews.org/commentaries/regulators-discover-a-hidden-viral-gene-in-commercial-gmo-crops/
 (Podevin and du Jardin 2012): http://www.es.landesbioscience.com/journals/gmcrops/article/21406/?nocache=1759778285
 Seralini et al. 2012: http://dx.doi.org/10.1016/j.fct.2012.08.005
 Latham and Wilson 2008: http://www.bioscienceresource.org/documents/BSR3-VirusTranscomplementation.pdf
 Safety Group Blows Lid on ‘Secret Virus’ Hidden in GMO Crops: http://www.prisonplanet.com/safety-group-blows-lid-on-%e2%80%98secret-virus%e2%80%99-hidden-in-gmo-crops-read-more-httpnaturalsociety-comsafety-group-blows-lid-on-secret-virus-hidden-in-gmo-cropsixzz2kd3cdjdv.html
 Genetically Modified Humans? New Gene-Altering Drug Paves Way for Mass Modification: http://www.prisonplanet.com/genetically-modified-humans-new-gene-altering-drug-paves-way-for-mass-modification.html
 Monsanto enters pharmaceutical business, acquires key ‘gene silencing’ technology for use in humans: http://www.prisonplanet.com/monsanto-enters-pharmaceutical-business-acquires-key-gene-silencing-technology-for-use-in-humans.html
 Deadly new disease linked to recent crop failures and animal miscarriages caused by GM crops, pesticides: http://www.prisonplanet.com/deadly-new-disease-linked-to-recent-crop-failures-and-animal-miscarriages-caused-by-gm-crops-pesticides.html
 Monsanto pushes bizarre conspiracy theory to deflect blame for GE wheat contamination of commercial crops: http://www.prisonplanet.com/monsanto-pushes-bizarre-conspiracy-theory-to-deflect-blame-for-ge-wheat-contamination-of-commercial-crops.html
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