December 12, 2011
Up to a fifth of patients being treated for depression with some medications may do worse than those given a placebo, according to a U.S. study.
The findings, published in Archives of General Psychiatry, highlight the importance of quickly identifying how patients respond to certain drugs, said lead author Ralitza Gueorguieva, at the Yale University School of Health.
“Identifying variables that are associated with response is a very important question that we haven’t quite tackled,” she said.
The researchers combined data from seven studies that randomly assigned patients to receive Eli Lilly’s drug Cymbalta, known generically as duloxetine, other antidepressants, or a drug-free pill for two months. The trials involved about 2,500 people with major depression.